{"id":992,"date":"2017-06-19T13:10:41","date_gmt":"2017-06-19T12:10:41","guid":{"rendered":"http:\/\/ibb.uab.cat\/?p=992"},"modified":"2017-06-20T08:40:48","modified_gmt":"2017-06-20T07:40:48","slug":"perfecting-prediction-of-mutational-impact-on-the-aggregation-propensity-of-the-als-associated-hnrnpa2-prion-like-protein-salvador-ventura","status":"publish","type":"post","link":"https:\/\/ibb.uab.cat\/index.php\/2017\/06\/19\/perfecting-prediction-of-mutational-impact-on-the-aggregation-propensity-of-the-als-associated-hnrnpa2-prion-like-protein-salvador-ventura\/","title":{"rendered":"Perfecting prediction of mutational impact on the aggregation propensity of the ALS-associated hnRNPA2 prion-like protein. Salvador Ventura"},"content":{"rendered":"<p>&nbsp;<\/p>\n<p><span style=\"color: #008080;\"><strong>Perfecting prediction of mutational impact on the aggregation propensity of the ALS-associated hnRNPA2 prion-like protein<\/strong><\/span><\/p>\n<p>Cristina Batlle, Mar\u00eda rosario Fern\u00e1ndez, Valent\u00edn Iglesias, Salvador Ventura<\/p>\n<p><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/1873-3468.12698\/full\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/1873-3468.12698\/full<\/a><\/p>\n<p>&nbsp;<\/p>\n<h2 style=\"text-align: justify;\">Abstract<\/h2>\n<p style=\"text-align: justify;\">\u00a0An increasing number of human proteins are being found to bear a prion-like domain (PrLD) driving the formation of membraneless compartments through liquid\u2013liquid phase separation. Point mutations in these PrLDs promote the transition to an amyloid-like state. There has been much debate on whether this aberrant aggregation is caused by compositional or sequential changes. A recent extensive mutational study of the ALS-associated prion-like hnRNPA2 protein provides a framework to discriminate the molecular determinants behind pathogenic PrLDs aggregation. The effect of mutations on the aggregation propensity of hnRNPA2 is best predicted by combining their impact on PrLD amino acid composition and sequence-based amyloid propensity. This opens an avenue for the prediction of disease causing mutations in other human prion-like proteins.<img loading=\"lazy\" class=\"alignright wp-image-994\" src=\"http:\/\/ibb.uab.cat\/wp-content\/uploads\/feb212698-fig-0001.png\" alt=\"\" width=\"324\" height=\"344\" srcset=\"https:\/\/ibb.uab.cat\/wp-content\/uploads\/feb212698-fig-0001.png 1064w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/feb212698-fig-0001-283x300.png 283w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/feb212698-fig-0001-768x815.png 768w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/feb212698-fig-0001-965x1024.png 965w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/feb212698-fig-0001-245x260.png 245w\" sizes=\"(max-width: 324px) 100vw, 324px\" \/><\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>&nbsp; Perfecting prediction of mutational impact on the aggregation propensity of the ALS-associated hnRNPA2 prion-like protein Cristina Batlle, Mar\u00eda rosario Fern\u00e1ndez, Valent\u00edn Iglesias, Salvador Ventura http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/1873-3468.12698\/full &nbsp; Abstract \u00a0An increasing number of human proteins are being found to bear a prion-like domain (PrLD) driving the formation of membraneless compartments through liquid\u2013liquid phase separation. Point mutations [&hellip;]<\/p>\n","protected":false},"author":65,"featured_media":993,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"_links":{"self":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/992"}],"collection":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/users\/65"}],"replies":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/comments?post=992"}],"version-history":[{"count":4,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/992\/revisions"}],"predecessor-version":[{"id":1004,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/992\/revisions\/1004"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media\/993"}],"wp:attachment":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media?parent=992"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/categories?post=992"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/tags?post=992"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}