{"id":4479,"date":"2022-03-01T10:12:45","date_gmt":"2022-03-01T09:12:45","guid":{"rendered":"https:\/\/ibb.uab.cat\/?p=4479"},"modified":"2022-03-01T10:13:43","modified_gmt":"2022-03-01T09:13:43","slug":"protein-folding-and-conformational-diseases-computational-methods-to-predict-protein-aggregation","status":"publish","type":"post","link":"https:\/\/ibb.uab.cat\/index.php\/2022\/03\/01\/protein-folding-and-conformational-diseases-computational-methods-to-predict-protein-aggregation\/","title":{"rendered":"Protein Folding and Conformational Diseases: &#8220;Computational methods to predict protein aggregation&#8221;"},"content":{"rendered":"\n<h6 id=\"publication-title\"><a href=\"https:\/\/www.sciencedirect.com\/journal\/current-opinion-in-structural-biology\"><strong>Current Opinion in Structural Biology<\/strong><\/a><\/h6>\n\n\n\n<p><a href=\"https:\/\/www.sciencedirect.com\/journal\/current-opinion-in-structural-biology\/vol\/73\/suppl\/C\">Volume 73<\/a>, April 2022, 102343<\/p>\n\n\n\n<p><a href=\"https:\/\/doi.org\/10.1016\/j.sbi.2022.102343\">https:\/\/doi.org\/10.1016\/j.sbi.2022.102343<\/a><\/p>\n\n\n\n<h2>Abstract<\/h2>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"alignright size-large is-resized\"><img loading=\"lazy\" src=\"https:\/\/ibb.uab.cat\/wp-content\/uploads\/1-s2.0-S0959440X21X0005X-cov200h.gif\" alt=\"\" class=\"wp-image-4480\" width=\"212\" height=\"275\"\/><\/figure><\/div>\n\n\n\n<p id=\"abspara0010\">In most cases, protein aggregation stems from the establishment of non-native intermolecular contacts. The formation of insoluble protein aggregates is associated with many human diseases and is a major bottleneck for the industrial production of protein-based therapeutics. Strikingly, fibrillar aggregates are naturally exploited for structural scaffolding or to generate molecular switches and can be artificially engineered to build up multi-functional nanomaterials. Thus, there is a high interest in rationalizing and forecasting protein aggregation. Here, we review the available computational toolbox to predict protein aggregation propensities, identify sequential or structural aggregation-prone regions, evaluate the impact of mutations on aggregation or recognize prion-like domains. We discuss the strengths and limitations of these algorithms and how they can evolve in the next future.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Current Opinion in Structural Biology Volume 73, April 2022, 102343 https:\/\/doi.org\/10.1016\/j.sbi.2022.102343 Abstract In most cases, protein aggregation stems from the establishment of non-native intermolecular contacts. The formation of insoluble protein aggregates is associated with many human diseases and is a major bottleneck for the industrial production of protein-based therapeutics. Strikingly, fibrillar aggregates are naturally exploited [&hellip;]<\/p>\n","protected":false},"author":65,"featured_media":4480,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"_links":{"self":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/4479"}],"collection":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/users\/65"}],"replies":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/comments?post=4479"}],"version-history":[{"count":2,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/4479\/revisions"}],"predecessor-version":[{"id":4482,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/4479\/revisions\/4482"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media\/4480"}],"wp:attachment":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media?parent=4479"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/categories?post=4479"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/tags?post=4479"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}