{"id":4020,"date":"2021-06-08T16:33:00","date_gmt":"2021-06-08T15:33:00","guid":{"rendered":"https:\/\/ibb.uab.cat\/?p=4020"},"modified":"2021-06-09T16:33:26","modified_gmt":"2021-06-09T15:33:26","slug":"celular-immunology-new-paradigm-in-nkt-cell-antigens-mcs-0208-2-hydroxymethylphenylthio-phytoceramide-an-aryl-phytoceramide-compound-with-a-single-hydroxyl-group-stimulates-nkt-cells","status":"publish","type":"post","link":"https:\/\/ibb.uab.cat\/index.php\/2021\/06\/08\/celular-immunology-new-paradigm-in-nkt-cell-antigens-mcs-0208-2-hydroxymethylphenylthio-phytoceramide-an-aryl-phytoceramide-compound-with-a-single-hydroxyl-group-stimulates-nkt-cells\/","title":{"rendered":"Celular Immunology: &#8220;New paradigm in NKT cell antigens: MCS-0208 (2-(Hydroxymethyl)phenylthio-phytoceramide) an aryl-phytoceramide compound with a single hydroxyl group stimulates NKT cells&#8221;"},"content":{"rendered":"\n<p>ChemMedChem.\u00a02021 Apr 6.\u00a0<\/p>\n\n\n\n<p><a href=\"\u00a010.1002\/cmdc.202000992\" target=\"_blank\" rel=\"noreferrer noopener\">doi: 10.1002\/cmdc.202000992.\u00a0Online ahead of print.<\/a><\/p>\n\n\n\n<div class=\"wp-block-image\"><figure class=\"alignright size-large is-resized\"><img loading=\"lazy\" src=\"https:\/\/ibb.uab.cat\/wp-content\/uploads\/cmdc.v16.11.cover_-772x1024.jpg\" alt=\"\" class=\"wp-image-4021\" width=\"357\" height=\"474\" srcset=\"https:\/\/ibb.uab.cat\/wp-content\/uploads\/cmdc.v16.11.cover_-772x1024.jpg 772w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/cmdc.v16.11.cover_-226x300.jpg 226w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/cmdc.v16.11.cover_-768x1018.jpg 768w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/cmdc.v16.11.cover_-196x260.jpg 196w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/cmdc.v16.11.cover_.jpg 834w\" sizes=\"(max-width: 357px) 100vw, 357px\" \/><\/figure><\/div>\n\n\n\n<h2>Abstract<\/h2>\n\n\n\n<p>NKT cells play an important role in the immune response and can be activated by glycolipids presented by CD1d protein. We present MCS-0208 an unprecedented arylthioether-phytoceramide able to induce potent iNKT cell activation, notably when tested in human iNKT cells. This arylsphingolipid analog has a simple phenyl group containing a single hydroxyl substituent as a surrogate of the sugar ring. The phenylthioether structure contrasts with a-galactosylceramide (1), the prototypical glycolipid used to induce iNKT cell stimulation, where the galactose 2&#8242;-OH and 3&#8242;-OH substituents are accepted as the minimal footprint and considered critical for NKT TCR recognition. A computational study supports the recognition of aromatic compound by the CD1d and TCR proteins as radically new structures for NKT cell stimulation.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>ChemMedChem.\u00a02021 Apr 6.\u00a0 doi: 10.1002\/cmdc.202000992.\u00a0Online ahead of print. Abstract NKT cells play an important role in the immune response and can be activated by glycolipids presented by CD1d protein. We present MCS-0208 an unprecedented arylthioether-phytoceramide able to induce potent iNKT cell activation, notably when tested in human iNKT cells. This arylsphingolipid analog has a simple [&hellip;]<\/p>\n","protected":false},"author":65,"featured_media":4021,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"_links":{"self":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/4020"}],"collection":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/users\/65"}],"replies":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/comments?post=4020"}],"version-history":[{"count":1,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/4020\/revisions"}],"predecessor-version":[{"id":4022,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/4020\/revisions\/4022"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media\/4021"}],"wp:attachment":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media?parent=4020"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/categories?post=4020"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/tags?post=4020"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}