{"id":3725,"date":"2020-11-02T20:05:12","date_gmt":"2020-11-02T19:05:12","guid":{"rendered":"https:\/\/ibb.uab.cat\/?p=3725"},"modified":"2020-11-02T20:06:19","modified_gmt":"2020-11-02T19:06:19","slug":"protein-folding-and-conformational-diseases-atomistic-fibrillar-architectures-of-polar-prion-inspired-heptapeptides","status":"publish","type":"post","link":"https:\/\/ibb.uab.cat\/index.php\/2020\/11\/02\/protein-folding-and-conformational-diseases-atomistic-fibrillar-architectures-of-polar-prion-inspired-heptapeptides\/","title":{"rendered":"Protein Folding and Conformational Diseases. &#8220;Atomistic fibrillar architectures of polar prion-inspired heptapeptides&#8221;"},"content":{"rendered":"<h3>\u00a0<\/h3>\n<h3 class=\"h--heading3 article-abstract__heading\" style=\"text-align: justify;\"><img loading=\"lazy\" class=\" wp-image-3726 alignleft\" src=\"https:\/\/ibb.uab.cat\/wp-content\/uploads\/get-salva.jpg\" alt=\"\" width=\"450\" height=\"220\" srcset=\"https:\/\/ibb.uab.cat\/wp-content\/uploads\/get-salva.jpg 378w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/get-salva-300x147.jpg 300w\" sizes=\"(max-width: 450px) 100vw, 450px\" \/><\/h3>\n<h3><span style=\"font-size: 12pt; color: #3366ff;\">https:\/\/doi.org\/10.1039\/D0SC05638C<\/span><\/h3>\n<h3 class=\"h--heading3 article-abstract__heading\" style=\"text-align: justify;\"><span style=\"font-size: 12pt; color: #3366ff;\">https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2020\/sc\/d0sc05638c#!divAbstract<\/span><\/h3>\n<h3 class=\"h--heading3 article-abstract__heading\" style=\"text-align: justify;\"><span style=\"font-size: 18pt;\">Abstract<\/span><\/h3>\n<div class=\"capsule__column-wrapper\">\n<div class=\"capsule__text\">\n<p style=\"text-align: justify;\">This article provides the computational prediction of the atomistic architectures resulting from self-assembly of the polar heptapeptide sequences NYNYNYN, SYSYSYS and GYGYGYG. Using a combination of molecular dynamics and a newly developed tool for non-covalent interaction analysis, we uncover the properties of a new class of bionanomaterials, including hydrogen-bonded polar zippers, and the relationship between peptide composition, fibril geometry and weak interaction networks. Our results, corroborated by experimental observations, provide the basis for the rational design of prion-inspired nanomaterials.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>\u00a0 https:\/\/doi.org\/10.1039\/D0SC05638C https:\/\/pubs.rsc.org\/en\/content\/articlelanding\/2020\/sc\/d0sc05638c#!divAbstract Abstract This article provides the computational prediction of the atomistic architectures resulting from self-assembly of the polar heptapeptide sequences NYNYNYN, SYSYSYS and GYGYGYG. Using a combination of molecular dynamics and a newly developed tool for non-covalent interaction analysis, we uncover the properties of a new class of bionanomaterials, including hydrogen-bonded polar zippers, [&hellip;]<\/p>\n","protected":false},"author":65,"featured_media":3728,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"_links":{"self":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/3725"}],"collection":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/users\/65"}],"replies":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/comments?post=3725"}],"version-history":[{"count":2,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/3725\/revisions"}],"predecessor-version":[{"id":3730,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/3725\/revisions\/3730"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media\/3728"}],"wp:attachment":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media?parent=3725"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/categories?post=3725"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/tags?post=3725"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}