{"id":3608,"date":"2020-10-07T11:18:22","date_gmt":"2020-10-07T10:18:22","guid":{"rendered":"https:\/\/ibb.uab.cat\/?p=3608"},"modified":"2020-11-11T23:12:33","modified_gmt":"2020-11-11T22:12:33","slug":"ph-d-contract-at-the-protein-folding-and-conformational-diseases-lab-at-the-uab","status":"publish","type":"post","link":"https:\/\/ibb.uab.cat\/index.php\/2020\/10\/07\/ph-d-contract-at-the-protein-folding-and-conformational-diseases-lab-at-the-uab\/","title":{"rendered":"Ph.D. contract at the Protein Folding and Conformational Diseases Lab at the UAB"},"content":{"rendered":"<p><a href=\"https:\/\/ibb.uab.cat\/wp-content\/uploads\/pc.pdf\" target=\"_blank\" rel=\"noopener\"><img loading=\"lazy\" class=\"alignleft wp-image-3610 size-medium\" src=\"https:\/\/ibb.uab.cat\/wp-content\/uploads\/PredocContract-2020-211x300.jpg\" alt=\"\" width=\"211\" height=\"300\" srcset=\"https:\/\/ibb.uab.cat\/wp-content\/uploads\/PredocContract-2020-211x300.jpg 211w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/PredocContract-2020-768x1090.jpg 768w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/PredocContract-2020-721x1024.jpg 721w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/PredocContract-2020-183x260.jpg 183w\" sizes=\"(max-width: 211px) 100vw, 211px\" \/><\/a>The Protein Folding and Conformational Diseases Lab at the Institut de Biotecnologia i<br \/>\nde Biomedicina of the Universitat Aut\u00f2noma de Barcelona (UAB), led by Prof. Salvador<br \/>\nVentura (https:\/\/ibb.uab.cat), offers a Ph.D. contract (FPI, 4 years), founded by the<br \/>\nSpanish Ministry of Science and Innovation to work in the project \u201cProtein Aggregation:<br \/>\nBiomedical and Biotechnological Applications\u201d (PID2019-105017RB-I00).<br \/>\nResearch<\/p>\n<p><strong> Line 1:<\/strong><\/p>\n<p style=\"text-align: justify;\">\nProtein aggregation is associated with the pathogenesis of neurodegenerative<br \/>\ndisorders. There is an urgent need for diagnostic tools and modifying therapies for these<br \/>\nincurable diseases. This project intends to exploit our protein aggregation background<br \/>\nto provide early diagnostic methods and therapeutic solutions for two different<br \/>\ndisorders: Parkinson&#8217;s disease and the Tauopathies.<br \/>\n&#8211; Pujols, J. et. al. Chemical chaperones as novel drugs for Parkinson\u2019s disease. Trends in Molecular Medicine.<br \/>\n26(4):408-421 (2020).<br \/>\n&#8211; Pujols J, et. al. Small molecule inhibits \u03b1-synuclein aggregation, disrupts amyloid fibrils, and prevents degeneration<br \/>\nof dopaminergic neurons. Proc Natl Acad Sci U S A. 115(41):10481-10486 (2018)<\/p>\n<p>\n<strong>Research Line 2:<\/strong><\/p>\n<p style=\"text-align: justify;\">\nDespite their association with disease, the stable, hierarchical, and tuneable assembly<br \/>\nof amyloids make them exceptional building blocks in nanotechnology, endorsing<br \/>\nmaterials with properties that cannot be attained with any other organic or inorganic<br \/>\ncomponent. In our lab, we use protein design to develop self-assembled nanomaterials<br \/>\nwith novel functional applications, ranging from bio-catalysis to immunotherapy.<br \/>\n&#8211; Wang W, et. al. Prion soft amyloid core driven self-assembly of globular proteins into bioactive nanofibrils. Nanoscale<br \/>\n11(26):12680-12694 (2019)<br \/>\n&#8211; D\u00edaz-Caballero M, et. al. Minimalist Prion-Inspired Polar Self-Assembling Peptides. ACS Nano. 12 (6), 5394\u20135407<br \/>\n(2018).<\/p>\n<p>\n<strong>Applicant Profile<\/strong><\/p>\n<p>\nCandidates must hold a Master\u2019s degree in a related discipline and should enrol in a<br \/>\nPh.D. program at the UAB in 2020\/21. They should be highly motivated and able to work<br \/>\nindependently, with solid previous experience in protein biochemistry\/protein<br \/>\nbiophysics and molecular biology.<\/p>\n<p>\n<strong>Applications<\/strong><br \/>\nTo apply, send your CV, a short motivation letter describing why you do want to<br \/>\nincorporate into the group, your background, and technical skills, and a scan of the<br \/>\nCertified Academic Record to Salvador.Ventura@uab.es, before<\/p>\n","protected":false},"excerpt":{"rendered":"<p>The Protein Folding and Conformational Diseases Lab at the Institut de Biotecnologia i de Biomedicina of the Universitat Aut\u00f2noma de Barcelona (UAB), led by Prof. Salvador Ventura (https:\/\/ibb.uab.cat), offers a Ph.D. contract (FPI, 4 years), founded by the Spanish Ministry of Science and Innovation to work in the project \u201cProtein Aggregation: Biomedical and Biotechnological Applications\u201d [&hellip;]<\/p>\n","protected":false},"author":65,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[1],"tags":[],"_links":{"self":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/3608"}],"collection":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/users\/65"}],"replies":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/comments?post=3608"}],"version-history":[{"count":4,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/3608\/revisions"}],"predecessor-version":[{"id":3617,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/3608\/revisions\/3617"}],"wp:attachment":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media?parent=3608"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/categories?post=3608"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/tags?post=3608"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}