{"id":3321,"date":"2020-06-25T08:54:15","date_gmt":"2020-06-25T07:54:15","guid":{"rendered":"https:\/\/ibb.uab.cat\/?p=3321"},"modified":"2020-06-25T09:04:40","modified_gmt":"2020-06-25T08:04:40","slug":"nanobiotechnology-engineering-protein-nanoparticles-out-from-components-of-the-human-microbiome","status":"publish","type":"post","link":"https:\/\/ibb.uab.cat\/index.php\/2020\/06\/25\/nanobiotechnology-engineering-protein-nanoparticles-out-from-components-of-the-human-microbiome\/","title":{"rendered":"Nanobiotechnology \u201cEngineering Protein Nanoparticles Out from Components of the Human Microbiome&#8221;"},"content":{"rendered":"<p><img loading=\"lazy\" class=\" wp-image-3322 alignleft\" src=\"https:\/\/ibb.uab.cat\/wp-content\/uploads\/smallcover.jpg\" alt=\"\" width=\"478\" height=\"628\" srcset=\"https:\/\/ibb.uab.cat\/wp-content\/uploads\/smallcover.jpg 761w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/smallcover-228x300.jpg 228w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/smallcover-198x260.jpg 198w\" sizes=\"(max-width: 478px) 100vw, 478px\" \/><a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202001885\" target=\"_blank\" rel=\"noopener\">https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202001885<\/a><\/p>\n<p><a href=\"https:\/\/doi.org\/10.1002\/smll.202001885\" target=\"_blank\" rel=\"noopener\">https:\/\/doi.org\/10.1002\/smll.202001885<\/a><\/p>\n<h3 class=\"article-section__header main abstractlang_en main\" style=\"text-align: justify;\">Abstract<\/h3>\n<div class=\"article-section__content en main\">\n<p style=\"text-align: justify;\">Nanoscale protein materials are highly convenient as vehicles for targeted drug delivery because of their structural and functional versatility. Selective binding to specific cell surface receptors and penetration into target cells require the use of targeting peptides. Such homing stretches should be incorporated to larger proteins that do not interact with body components, to prevent undesired drug release into nontarget organs. Because of their low interactivity with human body components and their tolerated immunogenicity, proteins derived from the human microbiome are appealing and fully biocompatible building blocks for the biofabrication of nonreactive, inert protein materials within the nanoscale. Several phage and phage\u2010like bacterial proteins with natural structural roles are produced in\u00a0<i>Escherichia coli\u00a0<\/i>as polyhistidine\u2010tagged recombinant proteins, looking for their organization as discrete, nanoscale particulate materials. While all of them self\u2010assemble in a variety of sizes, the stability of the resulting constructs at 37 \u00b0C is found to be severely compromised. However, the fine adjustment of temperature and Zn<sup>2+<\/sup>\u00a0concentration allows the formation of robust nanomaterials, fully stable in complex media and under physiological conditions. Then, microbiome\u2010derived proteins show promise for the regulatable construction of scaffold protein nanomaterials, which can be tailored and strengthened by simple physicochemical approaches.<\/p>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>https:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/smll.202001885 https:\/\/doi.org\/10.1002\/smll.202001885 Abstract Nanoscale protein materials are highly convenient as vehicles for targeted drug delivery because of their structural and functional versatility. Selective binding to specific cell surface receptors and penetration into target cells require the use of targeting peptides. Such homing stretches should be incorporated to larger proteins that do not interact with body [&hellip;]<\/p>\n","protected":false},"author":65,"featured_media":3322,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"_links":{"self":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/3321"}],"collection":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/users\/65"}],"replies":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/comments?post=3321"}],"version-history":[{"count":4,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/3321\/revisions"}],"predecessor-version":[{"id":3329,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/3321\/revisions\/3329"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media\/3322"}],"wp:attachment":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media?parent=3321"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/categories?post=3321"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/tags?post=3321"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}