{"id":2630,"date":"2019-12-17T10:03:06","date_gmt":"2019-12-17T09:03:06","guid":{"rendered":"https:\/\/ibb.uab.cat\/?p=2630"},"modified":"2019-12-17T10:03:59","modified_gmt":"2019-12-17T09:03:59","slug":"dr-salvador-ventura","status":"publish","type":"post","link":"https:\/\/ibb.uab.cat\/index.php\/2019\/12\/17\/dr-salvador-ventura\/","title":{"rendered":"Dr. Salvador Ventura:  ZPD-2, a Small Compound That Inhibits \u03b1-Synuclein Amyloid Aggregation and Its Seeded Polymerization"},"content":{"rendered":"<p style=\"text-align: justify;\"><img loading=\"lazy\" class=\"wp-image-2631 alignleft\" src=\"https:\/\/ibb.uab.cat\/wp-content\/uploads\/fnmol-12-00306-g009.jpg\" alt=\"\" width=\"646\" height=\"523\" srcset=\"https:\/\/ibb.uab.cat\/wp-content\/uploads\/fnmol-12-00306-g009.jpg 2006w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/fnmol-12-00306-g009-300x243.jpg 300w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/fnmol-12-00306-g009-768x622.jpg 768w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/fnmol-12-00306-g009-1024x830.jpg 1024w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/fnmol-12-00306-g009-321x260.jpg 321w\" sizes=\"(max-width: 646px) 100vw, 646px\" \/>Front. Mol. Neurosci., 17 December 2019 |\u00a0<a href=\"https:\/\/doi.org\/10.3389\/fnmol.2019.00306\">https:\/\/doi.org\/10.3389\/fnmol.2019.00306<\/a><\/p>\n<p style=\"text-align: justify;\">\u03b1-Synuclein (\u03b1-Syn) forms toxic intracellular protein inclusions and transmissible amyloid structures in Parkinson\u2019s disease (PD). Preventing \u03b1-Syn self-assembly has become one of the most promising approaches in the search for disease-modifying treatments for this neurodegenerative disorder. Here, we describe the capacity of a small molecule (ZPD-2), identified after a high-throughput screening, to inhibit \u03b1-Syn aggregation. ZPD-2 inhibits the aggregation of\u00a0<i>wild-type<\/i>\u00a0\u03b1-Syn and the A30P and H50Q familial variants\u00a0<i>in vitro<\/i>\u00a0at substoichiometric compound:protein ratios. In addition, the molecule prevents the spreading of \u03b1-Syn seeds in protein misfolding cyclic amplification assays. ZPD-2 is active against different \u03b1-Syn strains and blocks their seeded polymerization. Treating with ZPD-2 two different PD\u00a0<i>Caenorhabditis elegans<\/i>\u00a0models that express \u03b1-Syn either in muscle or in dopaminergic (DA) neurons substantially reduces the number of \u03b1-Syn inclusions and decreases synuclein-induced DA neurons degeneration. Overall, ZPD-2 is a hit compound worth to be explored in order to develop lead molecules for therapeutic intervention in PD.<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Front. Mol. Neurosci., 17 December 2019 |\u00a0https:\/\/doi.org\/10.3389\/fnmol.2019.00306 \u03b1-Synuclein (\u03b1-Syn) forms toxic intracellular protein inclusions and transmissible amyloid structures in Parkinson\u2019s disease (PD). Preventing \u03b1-Syn self-assembly has become one of the most promising approaches in the search for disease-modifying treatments for this neurodegenerative disorder. Here, we describe the capacity of a small molecule (ZPD-2), identified after [&hellip;]<\/p>\n","protected":false},"author":65,"featured_media":2631,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"_links":{"self":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/2630"}],"collection":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/users\/65"}],"replies":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/comments?post=2630"}],"version-history":[{"count":2,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/2630\/revisions"}],"predecessor-version":[{"id":2633,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/2630\/revisions\/2633"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media\/2631"}],"wp:attachment":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media?parent=2630"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/categories?post=2630"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/tags?post=2630"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}