{"id":2082,"date":"2019-01-10T12:10:27","date_gmt":"2019-01-10T11:10:27","guid":{"rendered":"https:\/\/ibb.uab.cat\/?p=2082"},"modified":"2019-01-10T12:11:42","modified_gmt":"2019-01-10T11:11:42","slug":"dr-a-villaverde-assembly-of-histidine-rich-protein-materials-controlled-through-divalent-cations-2","status":"publish","type":"post","link":"https:\/\/ibb.uab.cat\/index.php\/2019\/01\/10\/dr-a-villaverde-assembly-of-histidine-rich-protein-materials-controlled-through-divalent-cations-2\/","title":{"rendered":"Dr. A. Villaverde: \tEngineering a recombinant chlorotoxin as cell-targeted cytotoxic"},"content":{"rendered":"<p><a href=\"http:\/\/engine.scichina.com\/publisher\/scp\/journal\/SCMs\/doi\/10.1007\/s40843-018-9391-y?slug=abstract\" target=\"_blank\" rel=\"noopener\">http:\/\/engine.scichina.com\/publisher\/scp\/journal\/SCMs\/doi\/10.1007\/s40843-018-9391-y?slug=abstract<\/a><\/p>\n<p><img loading=\"lazy\" class=\"size-medium wp-image-2083 alignleft\" src=\"https:\/\/ibb.uab.cat\/wp-content\/uploads\/01_2019-223x300.jpg\" alt=\"\" width=\"223\" height=\"300\" srcset=\"https:\/\/ibb.uab.cat\/wp-content\/uploads\/01_2019-223x300.jpg 223w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/01_2019-768x1032.jpg 768w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/01_2019-762x1024.jpg 762w, https:\/\/ibb.uab.cat\/wp-content\/uploads\/01_2019-193x260.jpg 193w\" sizes=\"(max-width: 223px) 100vw, 223px\" \/><\/p>\n<div class=\"zhai_fl xihuanni\">\n<h3>Abstract<\/h3>\n<p class=\"introp\" style=\"text-align: justify;\">The controlled oligomerization of functional proteins at the nanoscale offers the possibility to design and produce, by recombinant DNA technologies, improved materials and drugs. A recombinant version of the scorpion toxin chlorotoxin (CTX), which has attracted interest due to its ability to preferentially bind cancer cells, has been engineered to self-assemble as regular 12 nm-nanoparticles that penetrate cultured cells with the same receptor-specificity than the natural toxin. These materials, that appear as promising, biocompatible and biodegradable drug carriers for cell-targeted therapy of glioma also exhibit a mild but still significant cytotoxic activity associated to the recombinant toxin, that simultaneously acts as both driver and therapeutic agent. In addition, the manipulation of the CTX-flanking regions shows a potent impact on the performance of the nanoparticles, supporting a high functional versatility of CTX-based constructs, regulatable by conventional genetic engineering.<\/p>\n<div id=\"funding\"><\/p>\n<h3 style=\"text-align: justify;\">Funded by<\/h3>\n<p style=\"text-align: justify;\">This study has been funded by the Agencia Estatal de Investigaci\u00f3n (AEI) and Fondo Europeo de Desarrollo Regional (FEDER) (grant BIO2016-76063-R, AEI\/FEDER, UE), AGAUR (2017SGR-229) and CIBER-BBN (project VENOM4CANCER) granted to AV, ISCIII (PI15\/00272 co-founding FEDER) to EV. RD received an overseas predoctoral fellowship from Conacyt (Gobierno de M\u00e9xico, 2016). LSG was supported by predoctoral fellowship from AGAUR (2018FI_B2_00051), NS was supported by a predoctoral fellowship from the Government of Navarra, and UU is supported by PERIS program from the health department of la Generalitat de Catalu\u00f1a. AV received an ICREA ACADEMIA award.<\/p>\n<\/div>\n<\/div>\n","protected":false},"excerpt":{"rendered":"<p>http:\/\/engine.scichina.com\/publisher\/scp\/journal\/SCMs\/doi\/10.1007\/s40843-018-9391-y?slug=abstract Abstract The controlled oligomerization of functional proteins at the nanoscale offers the possibility to design and produce, by recombinant DNA technologies, improved materials and drugs. A recombinant version of the scorpion toxin chlorotoxin (CTX), which has attracted interest due to its ability to preferentially bind cancer cells, has been engineered to self-assemble as regular [&hellip;]<\/p>\n","protected":false},"author":65,"featured_media":2083,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"_links":{"self":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/2082"}],"collection":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/users\/65"}],"replies":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/comments?post=2082"}],"version-history":[{"count":3,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/2082\/revisions"}],"predecessor-version":[{"id":2086,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/2082\/revisions\/2086"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media\/2083"}],"wp:attachment":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media?parent=2082"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/categories?post=2082"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/tags?post=2082"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}