{"id":1572,"date":"2018-06-24T21:42:27","date_gmt":"2018-06-24T20:42:27","guid":{"rendered":"http:\/\/ibb.uab.cat\/?p=1572"},"modified":"2018-06-24T21:50:16","modified_gmt":"2018-06-24T20:50:16","slug":"release-of-targeted-protein-nanoparticles-from-functional-bacterial-amyloids-a-death-star-like-approach","status":"publish","type":"post","link":"https:\/\/ibb.uab.cat\/index.php\/2018\/06\/24\/release-of-targeted-protein-nanoparticles-from-functional-bacterial-amyloids-a-death-star-like-approach\/","title":{"rendered":"Release of targeted protein nanoparticles from functional bacterial amyloids: A death star-like approach"},"content":{"rendered":"<p style=\"text-align: justify;\"><img loading=\"lazy\" class=\" wp-image-1573 alignright\" src=\"http:\/\/ibb.uab.cat\/wp-content\/uploads\/1-s2.0-S0168365918X00091-cov150h.gif\" alt=\"\" width=\"215\" height=\"285\" \/><span style=\"font-size: 14pt;\"><strong>Abstract<\/strong><\/span><\/p>\n<div id=\"as0005\" style=\"text-align: justify;\">\n<p id=\"sp0040\"><a title=\"Learn more about Time release technology\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/time-release-technology\">Sustained release<\/a>\u00a0of drug delivery systems (DDS) has the capacity to increase cancer treatment efficiency in terms of drug dosage reduction and subsequent decrease of deleterious side effects. In this regard, many\u00a0<a title=\"Learn more about Biomaterials\" href=\"https:\/\/www.sciencedirect.com\/topics\/materials-science\/biomaterials\">biomaterials<\/a>\u00a0are being investigated but none offers morphometric and functional\u00a0<a title=\"Learn more about Plasticity\" href=\"https:\/\/www.sciencedirect.com\/topics\/materials-science\/plasticity\">plasticity<\/a>\u00a0and versatility comparable to protein-based\u00a0<a title=\"Learn more about Nanoparticle\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/nanoparticle\">nanoparticles<\/a>\u00a0(pNPs). Here we describe a new DDS by which pNPs are fabricated as bacterial inclusion bodies (IB), that can be easily isolated, subcutaneously injected and used as reservoirs for the sustained release of targeted pNPs. Our approach combines the high performance of pNP, regarding specific cell targeting and\u00a0<a title=\"Learn more about Biodistribution\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/biodistribution\">biodistribution<\/a>\u00a0with the IB\u00a0<a title=\"Learn more about Supramolecular chemistry\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/supramolecular-chemistry\">supramolecular<\/a>\u00a0organization, stability and cost effectiveness. This renders a platform able to provide a sustained source of CXCR4-targeted pNPs that selectively accumulate in tumor cells in a CXCR4<sup>+<\/sup>\u00a0colorectal cancer xenograft model. In addition, the proposed system could be potentially adapted to any other protein construct offering a plethora of possible new therapeutic applications in\u00a0<a title=\"Learn more about Nanomedicine\" href=\"https:\/\/www.sciencedirect.com\/topics\/pharmacology-toxicology-and-pharmaceutical-science\/nanomedicine\">nanomedicine<\/a>.<\/p>\n<\/div>\n<p style=\"text-align: justify;\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0168365918301780\" target=\"_blank\" rel=\"noopener\">https:\/\/www.sciencedirect.com\/science\/article\/pii\/S0168365918301780<\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Abstract Sustained release\u00a0of drug delivery systems (DDS) has the capacity to increase cancer treatment efficiency in terms of drug dosage reduction and subsequent decrease of deleterious side effects. In this regard, many\u00a0biomaterials\u00a0are being investigated but none offers morphometric and functional\u00a0plasticity\u00a0and versatility comparable to protein-based\u00a0nanoparticles\u00a0(pNPs). Here we describe a new DDS by which pNPs are fabricated [&hellip;]<\/p>\n","protected":false},"author":65,"featured_media":1573,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"_links":{"self":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/1572"}],"collection":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/users\/65"}],"replies":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/comments?post=1572"}],"version-history":[{"count":5,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/1572\/revisions"}],"predecessor-version":[{"id":1578,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/1572\/revisions\/1578"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media\/1573"}],"wp:attachment":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media?parent=1572"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/categories?post=1572"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/tags?post=1572"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}