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Dr. Gian Tartaglia; biografia i l’abstract de la xerrada.<\/span><\/p>\n \u00a0<\/p>\n Biography:<\/b>\u00a0Gian graduated at the University La Sapienza in the academic year 1999-2000 with a thesis on mathematical modeling of neurons (Physics department, B.\u00a0Tirozzi). Between 2001 and 2005, he carried out his doctoral studies at the University of Zurich CH (Biochemistry department, A. Caflisch) focusing on the folding and\u00a0misfolding of proteins associated with neurodegenerative disorders. As a fellow of Clare Hall college, Gian worked at the University of Cambridge UK (Chemistry and\u00a0Genetics departments) under the supervision of C. Dobson and M. Vendruscolo. In the period 2005-2010, he participated in several computational and experimental studies\u00a0on amyloidosis supported by Swiss National Science Foundation (CH) and Medical Research Council (UK). In 2010 Gian started his own laboratory at the Centre for\u00a0Genomic Regulation (Bioinformatics and Genomics department; Barcelona, Spain) and was later tenured in 2014 by the Instituci\u00f3 Catalana de Recerca i Estudis Avan\u00e7ats\u00a0ICREA (Life and Medical Sciences).\u00a0His group, supported by the European Research Council and other grants such as Wellcome trust and Horizon H2020, collaborates\u00a0with a number of international partners (Annalisa Pastore \u2013 King\u2019s college London UK, Ina Vorberg \u2013 DZNE Bonn, Ulrich Hartl \u2013 Max Plank Munich DE and Peter Hyslop,\u00a0Cambridge UK to cite some).\u00a0\u00a0His present research focuses on both computational and experimental approaches to navigate the uncharted territory of molecules involved in\u00a0gene regulation (e.g., X-chromosome inactivation) as well as human disorders (e.g., Parkinson\u2019s disease).<\/span><\/p>\n Abstract<\/b>:\u00a0Nucleic acids and proteins are the most important biomolecules in any organism, with the former carrying genetic information and the latter executing and\u00a0regulating life processes. Characterizing protein interactions [1] is key to unravel the functionality of genomes [2] and can open up therapeutic avenues for the treatment of\u00a0a broad range of diseases. \u00a0In this talk, I will focus on the work done in my laboratory to study the role played by proteins and RNAs in transcriptional and translational\u00a0regulation as well as neurodegenerative disorders (examples include Parkinson\u2019s a-synuclein, Alzheimer\u2019s disease amyloid protein APP, TDP-43 and FUS)[3,4]. Using both\u00a0computational and experimental approaches, we aim to discover the involvement of RNA molecules in regulatory networks controlling protein production. More specifically, I\u00a0am interested in understanding mechanisms whose alteration lead to aberrant accumulation of proteins [5]. \u00a0We have previously observed that interactions between\u00a0proteins and their messenger RNAs induce feedback loops that are crucial in protein homeostasis [3,4]. \u00a0Recently, we started to work on the interactions of mystery\u00a0trascripts, the long non coding RNAs [6].<\/span><\/p>\n \u00a0<\/span><\/p>\n 1. \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Bellucci, M., Agostini, F., Masin, M. & Tartaglia, G. G. Predicting protein associations with RNAs. Nat. Methods 8, 444\u2013445 (2011).<\/span><\/p>\n 2. \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Cirillo, D. et al. Constitutive patterns of gene expression regulated by RNA-binding proteins. Genome Biol. 15, R13 (2014).<\/span><\/p>\n 3. \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 Zanzoni, A. et al. Principles of self-organization in biological pathways: a hypothesis on the autogenous association of alpha-synuclein. Nucleic Acids Res. 41, 9987\u20139998 (2013).<\/span><\/p>\n 4. \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Cirillo, D. et al. Neurodegenerative diseases: Quantitative predictions of protein-RNA interactions. RNA N. Y. N 19, 129\u2013140 (2013).<\/span><\/p>\n 5. \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Bolognesi, B. et al. A Concentration-Dependent Liquid Phase Separation Can Cause Toxicity upon Increased Protein Expression. Cell Rep. 16, 222\u2013231 (2016).<\/span><\/p>\n 6. \u00a0 \u00a0 \u00a0 \u00a0 \u00a0 \u00a0Cirillo D, et al. Quantitiative predicitons of protein interactions with long non coding RNAs. Nat Methods. 2017 Jan 1;14(1):5-6. doi: 10.1038\/nmeth.4100\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":" Dr. Gian Tartaglia; biografia i l’abstract de la xerrada. \u00a0 Biography:\u00a0Gian graduated at the University La Sapienza in the academic year 1999-2000 with a thesis on mathematical modeling of neurons (Physics department, B.\u00a0Tirozzi). Between 2001 and 2005, he carried out his doctoral studies at the University of Zurich CH (Biochemistry department, A. Caflisch) focusing on […]<\/p>\n","protected":false},"author":65,"featured_media":0,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[5],"tags":[],"_links":{"self":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/1511"}],"collection":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/users\/65"}],"replies":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/comments?post=1511"}],"version-history":[{"count":2,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/1511\/revisions"}],"predecessor-version":[{"id":1514,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/1511\/revisions\/1514"}],"wp:attachment":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media?parent=1511"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/categories?post=1511"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/tags?post=1511"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}