{"id":1450,"date":"2018-02-06T10:50:29","date_gmt":"2018-02-06T09:50:29","guid":{"rendered":"http:\/\/ibb.uab.cat\/?p=1450"},"modified":"2018-02-06T10:51:26","modified_gmt":"2018-02-06T09:51:26","slug":"dr-antoni-villaverde-self-assembling-toxin-based-nanoparticles-as-self-delivered-antitumoral-drugs","status":"publish","type":"post","link":"https:\/\/ibb.uab.cat\/index.php\/2018\/02\/06\/dr-antoni-villaverde-self-assembling-toxin-based-nanoparticles-as-self-delivered-antitumoral-drugs\/","title":{"rendered":"Dr. Antoni Villaverde: Self-assembling toxin-based nanoparticles as self-delivered antitumoral drugs"},"content":{"rendered":"<p style=\"text-align: justify;\"><a href=\"https:\/\/www.sciencedirect.com\/science\/article\/pii\/S016836591830049X\"><img loading=\"lazy\" class=\"wp-image-1451 alignleft\" src=\"http:\/\/ibb.uab.cat\/wp-content\/uploads\/cover06-02-2018.gif\" alt=\"\" width=\"395\" height=\"524\" \/><\/a>https:\/\/www.sciencedirect.com\/science\/article\/pii\/S016836591830049X<\/p>\n<p style=\"text-align: justify;\">\u00a0<\/p>\n<p style=\"text-align: justify;\">\u00a0<\/p>\n<div class=\"abstract svAbstract \" data-etype=\"ab\">\n<h2 id=\"authorab00051\" class=\"secHeading\" style=\"text-align: justify;\">Abstract<\/h2>\n<p id=\"sp0040\" style=\"text-align: justify;\">Loading capacity and drug leakage from vehicles during circulation in blood is a major concern when developing nanoparticle-based cell-targeted cytotoxics. To circumvent this potential issue it would be convenient the engineering of drugs as self-delivered nanoscale entities, devoid of any heterologous carriers. In this context, we have here engineered potent protein toxins, namely segments of the diphtheria toxin and the <em>Pseudomonas aeruginosa<\/em> exotoxin as self-assembling, self-delivered therapeutic materials targeted to CXCR4<sup>+<\/sup> cancer stem cells. The systemic administration of both nanostructured drugs in a colorectal cancer xenograft mouse model promotes efficient and specific local destruction of target tumor tissues and a significant reduction of the tumor volume. This observation strongly supports the concept of intrinsically functional protein nanoparticles, which having a dual role as drug and carrier, are designed to be administered without the assistance of heterologous vehicles.<\/p>\n<\/div>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n<p>&nbsp;<\/p>\n","protected":false},"excerpt":{"rendered":"<p>https:\/\/www.sciencedirect.com\/science\/article\/pii\/S016836591830049X \u00a0 \u00a0 Abstract Loading capacity and drug leakage from vehicles during circulation in blood is a major concern when developing nanoparticle-based cell-targeted cytotoxics. To circumvent this potential issue it would be convenient the engineering of drugs as self-delivered nanoscale entities, devoid of any heterologous carriers. In this context, we have here engineered potent protein [&hellip;]<\/p>\n","protected":false},"author":65,"featured_media":1451,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"_links":{"self":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/1450"}],"collection":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/users\/65"}],"replies":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/comments?post=1450"}],"version-history":[{"count":1,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/1450\/revisions"}],"predecessor-version":[{"id":1452,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/1450\/revisions\/1452"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media\/1451"}],"wp:attachment":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media?parent=1450"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/categories?post=1450"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/tags?post=1450"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}