{"id":1119,"date":"2017-07-12T12:31:57","date_gmt":"2017-07-12T11:31:57","guid":{"rendered":"http:\/\/ibb.uab.cat\/?p=1119"},"modified":"2017-07-12T12:31:57","modified_gmt":"2017-07-12T11:31:57","slug":"peptide-based-nanostructured-materials-with-intrinsic-proapoptotic-activities-in-cxcr4-solid-tumors","status":"publish","type":"post","link":"https:\/\/ibb.uab.cat\/index.php\/2017\/07\/12\/peptide-based-nanostructured-materials-with-intrinsic-proapoptotic-activities-in-cxcr4-solid-tumors\/","title":{"rendered":"Peptide-Based Nanostructured Materials with Intrinsic Proapoptotic Activities in CXCR4+ Solid Tumors"},"content":{"rendered":"<p><span style=\"color: #008080;\"><strong>Peptide-Based Nanostructured Materials with Intrinsic Proapoptotic Activities in CXCR4+ Solid Tumors<\/strong><\/span><\/p>\n<p>\ufffcNaroa Serna, \ufffcMar\u00eda Virtudes C\u00e9spedes, \ufffcLaura S\u00e1nchez-Garc\u00eda, \ufffcUgutz Unzueta, \ufffcRita Sala, \ufffcAlejandro S\u00e1nchez-Chardi, \ufffcFrancisco Cort\u00e9s, \ufffcNeus Ferrer-Miralles, \ufffcRam\u00f3n Mangues, \ufffcEsther V\u00e1zquez, \ufffcAntonio Villaverde<\/p>\n<p><a href=\"http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/adfm.201700919\/full\">http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/adfm.201700919\/full<\/a><\/p>\n<h2>Abstract<\/h2>\n<p>Protein materials are gaining interest in nanomedicine because of the unique combination of regulatable function and structure. A main application of protein nanoparticles is as vehicles for cell-targeted drug delivery in the form of nanoconjugates, in which a conventional or innovative drug is associated to a carrier protein. Here, a new nanomedical approach based on self-assembling protein nanoparticles is developed in which a chemically homogeneous protein material acts, simultaneously, as vehicle and drug. For that, three proapoptotic peptidic factors are engineered to self-assemble as protein-only, fully stable nanoparticles that escape renal clearance, for the multivalent display of a CXCR4 ligand and the intracellular delivery into CXCR4+ colorectal cancer models. These materials, produced and purified in a single step from bacterial cells, show an excellent biodistribution upon systemic administration and local antitumoral effects. The design and generation of intrinsically therapeutic protein-based materials offer unexpected opportunities in targeted drug delivery based on fully biocompatible, tailor-made constructs.<\/p>\n","protected":false},"excerpt":{"rendered":"<p>Peptide-Based Nanostructured Materials with Intrinsic Proapoptotic Activities in CXCR4+ Solid Tumors \ufffcNaroa Serna, \ufffcMar\u00eda Virtudes C\u00e9spedes, \ufffcLaura S\u00e1nchez-Garc\u00eda, \ufffcUgutz Unzueta, \ufffcRita Sala, \ufffcAlejandro S\u00e1nchez-Chardi, \ufffcFrancisco Cort\u00e9s, \ufffcNeus Ferrer-Miralles, \ufffcRam\u00f3n Mangues, \ufffcEsther V\u00e1zquez, \ufffcAntonio Villaverde http:\/\/onlinelibrary.wiley.com\/doi\/10.1002\/adfm.201700919\/full Abstract Protein materials are gaining interest in nanomedicine because of the unique combination of regulatable function and structure. A main [&hellip;]<\/p>\n","protected":false},"author":551,"featured_media":1122,"comment_status":"closed","ping_status":"open","sticky":false,"template":"","format":"standard","meta":[],"categories":[4],"tags":[],"_links":{"self":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/1119"}],"collection":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/users\/551"}],"replies":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/comments?post=1119"}],"version-history":[{"count":3,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/1119\/revisions"}],"predecessor-version":[{"id":1124,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/posts\/1119\/revisions\/1124"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media\/1122"}],"wp:attachment":[{"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/media?parent=1119"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/categories?post=1119"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/ibb.uab.cat\/index.php\/wp-json\/wp\/v2\/tags?post=1119"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}